Thomas H. Grohser discusses the challenges of designing a robust backup and restore solutions for very large databases (VLDBs) in this SQL Server Technical Article:

http://download.microsoft.com/download/d/9/4/d948f981-926e-40fa-a026-5bfcf076d9b9/Technical%20Case%20Study-Backup%20VLDB%20Over%20Network_Final.docx

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